Showing posts with label JUNO. Show all posts
Showing posts with label JUNO. Show all posts

Wednesday, August 10, 2016

Ziopharm - What happens when the excitement wears off?

I have been following Ziopharm since March of 2015 when it popped onto a lot of radar screens. After paying the MD Anderson Cancer Center $50 million in stock for a partnership agreement (and another $7.5 million to expedite the deal) the ZIOP symbol started showing up all over message boards and social media sites where public companies are discussed.

We all know what happened of course, after getting up near $15 in 2015 shares of ZIOP cratered, recently trading for less than $5.  That is until today.

The company released its 10Q yesterday (after market close Aug 9th) and conducted a conference call, the transcript for which is available on Seeking Alpha HERE.  Pre-market activity likely got some excited in my opinion, as the PPS climbed back over $5.  Shares traded as high as $5.30 before the open, and when the bell rang at 9:30 the climb continued.  ZIOP quickly jumped as high as $5.48 for a gain over over 12% from the previous day's close of $4.86

Whether you're invested in ZIOP or not (either long or short) this type of activity is instructive I believe.  When companies are burning cash and selling forward looking promise excitement is almost a commodity in of itself.  And Ziopharm has a long history of generating excitement, in tandem with a massive accumulated deficit that is now over $600 million and growing.

Overall ZIOP finished the day in positive territory, closing at $5.14, after retreating from that $5.48 inter-day high.

Retail investors have a reputation for being focused on price, to the exclusion of almost everything else.  If someone shows up on CNBC and starts screaming BUY BUY BUY for a stock, and if it starts climbing....typical retail players get excited and don't even worry about who is selling or why.  

Conference Calls are a great way to drum up buyers, especially with purely speculative money burning companies relying on forward looking promise to attract investors in my opinion. 

I'm not suggesting there weren't solid positives on the CC, there were.  There's some pre-clinical initiatives which I assume will be with mice, and that's good news for the rodent world.  And the company seems to be progressing with its phase I safety trial which clinicaltrials.gov shows as having a "study completion date" of December 2018, or about one year after the company projects its financial resources will run out.

On the financial side there was very little said, but that is something I expect with speculative companies seeking financing.  A Conference Call is about stressing the positives, so I wasn't suprised to see very little discussion of something so mundane and depressing as raising capital.  According to the transcript of the call this is what was said:

"We have cash, we have a cash runway through essentially the end of 2017..." (emphasis mine)

So all in all, at least in the short term, there's plenty to be excited about.  Obviously going forward they're going to be needing to raise cash, but that's in the actual 10Q filing and a lot of retailers can't be bothered to read it I bet.

We shall see what happens if and when the excitement that gave the share price this little bump wears off.  Or was there enough to sustain it for a while?  Like when they made the Anderson announcement at JP Morgan's Healthcare conference.  Personally I don't think so, but that is opinion....an opinion based partly on the lack of significant analyst participation.  

Companies like JUNO and KITE are getting analysts from the JP Morgans, Citibanks, and Goldman Sachs of the street.  Both Juno and Kite had over 10 analysts on their recent calls including those big boys.  Ziopharm on the other hand only had two, from Raymond James and Griffin, which in my view don't have near the profile and reach of the analysts covering the CAR T leaders.  



Thursday, July 21, 2016

Juno Therapeutics being sued - Is Ziopharm next?

The shine has definitely come off the CAR-T space.  

If you're reading this miserable little blog then I assume you're already familiar with Chimeric Antigen Receptors and how they can allow T cells to recognize a specific protein (or antigen) on a tumor cell. And with the issue of toxicity and how the companies in this space are attempting to overcome it. 

This new and exciting field caught fire in 2014 and 2015 as investors stormed into companies investigating potential treatments for various forms of cancer using this new Immunotherapy.

Kite Pharma (Nasdaq KITE) started trading in June of 2014 around $25 per share, and it didn't take long for it to take off, getting up around $90 by January 2015 and again in November of the same year.  KITE is currently trading around $50 per share with a market cap of around $2.5 Billion.

At $50.18 (the most recent close) KITE is trading 44.1% below its 52 week high of $89.84

Juno Therapeutics (Nasdaq JUNO) started trading in December of 2014 in the $35 to $40 range and it too soared, getting up near $70 by June of 2015.  JUNO is currently trading under $30 with a market cap of a little over $3 billion.

At $28.83 (the most recent close) JUNO is trading 50.1% below its 52 week high of $57.82

Ziopharm jumped into the CAR T space in January of 2015 after reaching an agreement with the MD Anderson Cancer Center in tandem with partner company Intrexon that included paying Anderson $100 million in shares of the two companies ($50 million each) plus an additional $15 million in shares (also split evenly) to induce Anderson to agree to the deal in time for a JP Morgan healthcare investor conference.

Shares of Ziopharm did as might be expected.  After trading under $3 as recently as October of 2014, by March of 2015 they were trading over $14, and ZIOP reached those levels again as recently as November of last year.  ZIOP is currently trading under $5 per share with a market cap of about $600 million.  

At $4.60 (the most recent close) ZIOP is trading 69.1% below its 52 week high of $14.93

Juno Therapeutics has recently become the target of law suits centred around allegations of violations of Federal Security Laws regarding the reporting of a Phase II trial patient death, and that insiders engaged in the selling of shares before the news was released on July 7th 2016.  Before news of the patient death JUNO had been trading around $40, after the news came out the PPS dropped down to its current price around $28.  

Here is a link with details of one lawsuit:


Ziopharm also recently reported a patient death in its Phase I trial for Ad-RTS-hIL-12.  And as with JUNO the news sent ZIOP's shares sharply lower.  Trading in and around $6 in the days prior to the news, shares dropped under $5 on July 15th and closed today's trading at $4.60  There have also been stories written saying Ziopharm was in discussions in regards to a possible $50 million equity offering that has since been withdrawn in the wake of the trial news.  


This news has also attracted various law firms, with PRs announcing that Ziopharm is being investigated for possible breaches of Federal Security laws.  

Here are some links from law firms seeking to contact Ziopharm shareholders in regards to their investigations:








Does all this activity mean Ziopharm, like Juno, will be sued?  I don't know, I'm not a lawyer.  The extent of my legal expertise comes largely from reading about a dozen John Grishman novels and watching old episodes of Law & Order.

I do know that this is one of the many risk factors outlined in Ziopharm's SEC Filings.  From their most recent 10Q you will find this:  

The testing and marketing of medical products entail an inherent risk of product liability. If we cannot successfully defend ourselves against product liability claims, we may incur substantial liabilities or be required to limit commercialization of our products, if approved. Even a successful defense would require significant financial and management resources. Regardless of the merit or eventual outcome, liability claims may result in:

Decreased demand for our product candidates;

Injury to our reputation;

Withdrawal of clinical trial participants;

Withdrawal of prior governmental approvals;

Costs of related litigation;

Substantial monetary awards to patients;

Product recalls;

Loss of revenue; and

The inability to commercialize our product candidates.
We currently carry clinical trial insurance and product liability insurance. However, an inability to renew our policies or to obtain sufficient insurance at an acceptable cost could prevent or inhibit the commercialization of pharmaceutical products that we develop, alone or with collaborators.

There is of course insurance for possible securities violations, which is included in a Schedule 14a filing:  


We maintain director and officer insurance providing for indemnification of our directors and officers for certain liabilities, including certain liabilities under the Securities Act. We also maintain a general liability insurance policy that covers certain liabilities of directors and officers arising out of claims based on acts or omissions in their capacities as directors or officers. We have also entered into indemnification agreements with each of our directors and named executive officers.

I don't know what "certain" liabilities means.  Obviously it means some, but all.  So whether they are insured or not...the devil, as is often said, is in the details.

Too often inexperienced investors rush into a stock on hype, excitement and a climbing share price.

It pays to be fully abreast of all the risk factors.